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Gilead sets coronavirus drug candidate remdesivir at $2,340 per patient

Gilead Sciences Inc on Monday priced its COVID-19 antiviral remdesivir at $2,340 per patient for wealthier nations and agreed to send nearly all of its supply of the drug to the United States over the next three months. The price tag is slightly below the range of $2,520 to $2,800 suggested last week by US drug pricing research group the Institute for Clinical and Economic Review (ICER) after British researchers said they found that the cheap, widely available steroid dexamethasone significantly reduced mortality among severely ill COVID-19 patients. Remdesivir is expected to be in high demand as one of the only treatments shown to alter the course of COVID-19. After the intravenously administered medicine helped shorten hospital recovery times in a clinical trial, it won emergency use authorization in the United States and full approval in Japan. For US patients with commercial insurance, Gilead said it will charge $3,120 for a five-day treatment course, or $520 per vial. That is a 33% increase over the $390 per vial Gilead said it will charge governments of developed countries and US patients in government healthcare programs. In an open letter, Gilead Chief Executive Daniel O Day said the price is well below the value it provides given that early hospital discharges could save around $12,000 per patient in the United States. Patient advocates like Public Citizen argue that the cost should be lower since remdesivir was developed with financial support from the US government. Peter Maybarduk, director of Public Citizen’s Access to Medicines Program, called the price an offensive display of hubris and disregard for the public. While the drug modestly reduced hospital stays, it has not been shown to reduce deaths in COVID-19 patients. Gilead also said it agreed to continue to send its supply of remdesivir to the US Department of Health and Human Services (HHS), with the agency and states set to manage allocation to US hospitals until the end of September. HHS said it secured more than 500,000 remdesivir courses for US hospitals through September, which represents all of Gilead s projected production for July and 90% of its production in August and September, in addition to an allocation for clinical trials, HHS said. Once supplies are less constrained, HHS will stop managing the allocation, Gilead said. The company did not discuss its supply strategy for developed nations outside the United States. Remdesivir s price has been a topic of intense debate since US regulators approved its emergency use in some COVID-19 patients in May. Experts have said Gilead would need to avoid appearing to take advantage of a health crisis for profits. Gilead shares were about flat in midday trading. The European Union s healthcare regulator last week recommended conditional approval of the drug when used in the critically ill. The formal go-ahead by the European Commission is expected to follow soon. Gilead has linked up with generic drugmakers based in India and Pakistan, including Cipla Ltd and Hetero Labs Ltd, to make and supply remdesivir in 127 developing countries. Cipla s version is priced at less than 5,000 Indian rupees ($66.24), while Hetero Lab s version is priced at 5,400 rupees ($71.54).


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